Hope in the Darkness... A New Drug to Treat Metastatic Pancreatic Cancer

There's a new drug on the block... And Earl Groce wants everyone to know about it!

His story is one of Hope and an amazing 5+ years of living with (and thriving in the midst of) pancreatic cancer.

He shares so much of the journey on his blog... cpi613.com.  Head over there right now and be encouraged!

His story starts out as many before him... utter shock, disbelief and despair.  Pancreatic cancer is among the top deadliest cancers in America and has a dismal survival rate if the cancer has spread or metastasized.

And Earl's cancer had spread from the pancreas to the liver and lungs before being diagnosed.  It's a diagnosis none of us would wish to receive.

But... Earl's doctor was able to enroll him into a new clinical trial.  He was one of 20 patients in the first phase.  And this is the story he is telling to all who will listen.  We need more cancer patients and loved ones to hear the news.  Check out his blog... he shares it well!

The new drug CPI613 or Devimistat works in tandem with a modified Folfirinox treatment and in November of 2020, the FDA has fast tracked CPI613 for Pancreatic Cancer treatment.  It is currently in Phase 3 trials and while not the golden ticket for everyone, it has improved remission and given hope to many!

Earl received a beautiful thank you note from the daughter of a fellow pancreatic cancer patient.  She shares from her heart and it resonates deeply:

"Thank you for everything, and please keep sharing your story.  I KNOW we are not the only family you have given hope to in some of the darkest times.  This diagnosis is given as a death sentence by doctors, and a quick internet search turns up much of the same.  Your story is one of so few out there that shed light on such a grim diagnosis.  Thank you again."

Well done Mr. Groce!  Well done!  We need more Hope for the Darkness.  Thank you for being the encouragement we all need!

Prayers tonight for the cancer warriors and each one who is holding the line.  CPI613 is one of the newest drugs in the fight to win this war.  Believing with all my heart it is just the beginning...

All My Love,
Jane

A Clinical Trial Success Story!

We need more success stories like this!

Come meet Earl...

In September 2015, Earl returned home to North Carolina after driving 5,500 miles cross-country for his first trip to the Burning Man festival in Nevada.  Concerned about a herniated belly button, he went to see his doctor.  Earl assumed the long, hard drive in his camper without power steering had put too much stress on his body.  The doctor came back with a diagnosis that was the furthest thing from his mind - stage IV pancreatic cancer, with metastases in his liver, lungs and fatty tissue.

Earl asked to call in his daughter, a physician,  Reflecting on that conversation, she says, "When you're hoping for the diagnosis to be melanoma, you know it's a very bad day."  Having treated pancreatic cancer patients herself, she understood they would have to act fast to make treatment decisions. 

His daughter immediately called colleagues to ask for referrals and flew to be with her father in North Carolina.  Reunited at the airport, the family cried and hugged before they left to start the process of setting a treatment plan.  They chose an expert medical team at Wake Forest Baptist Medical Center that his daughter describes as "an amazing team of doctors and nurses who were always enthusiastic, upbeat, caring and hopeful."

While discussing treatment options, Earl's doctor suggested a clinical trial.  Earl says, "I saw it as an opportunity to get the best drugs hospitals could offer, plus more." His daughter adds, "We know that clinical trials offer the newest and often best, options for treatment."  Earl enrolled in a phase I clinical trial for CPI-613, a targeted therapy aimed at cancer cell metabolism, receiving the test drug in addition to Folfirinox, a combination of chemotherapeutic agents.

After four rounds of the regimen, Earl's tumors shrank by as much as 30%.  One year after diagnosis, he was feeling great and his CA19-9 levels had come down from around 10,000 to below normal range.

Early in his treatment, he took a trip to Disneyland with his grandchildren.  Since then, he and his wife, Juanita, have visited family in Canada seven times and gone on many family trips across the United States, including a camping trip in Yellowstone National Park.  Earl and his wife have also made the cross-country road trip to the Burning Man festival again - twice.  Earl says, "Even though it can be hard, I remained hopeful, positive and optimistic throughout the treatment."  To help maintain his positive attitude, Earl and his family made a point to spend extra time together, which has brought them even closer. 

Reflecting on his family, Earl says, "They have been so supportive - especially my wife of 49 years, Juanita.  I recently told her she may have to put up with me for another 15 years!  It is an understatement to say I'm a proud husband, father and grandpa."

Earl wants to deliver a message of hope that pancreatic cancer is not a death sentence.  He encourages others facing the disease to find an expert healthcare team, actively seek out clinical trials and try to maintain a positive attitude.  His daughter, speaking as both a family member and a physician, echoes this advice, saying, "When you're choosing a healthcare team, you must consider their experience and treatment philosophy - it will impact your entire experience.  Seek out the type of team you want and always consider clinical trials because they are very important treatment options."  Earl is currently receiving treatments with CT and MRI scans after every four rounds.  His scans have been clear for months, and his CA19-9 levels remain below normal.  He still feels good, though his many adventures cause him to be tired sometimes.  He says, "I'm extremely active for a 70-year-old pancreatic cancer patient, and I don't plan to slow down because I'm on borrowed time."

These are the stories that make my heart happy!

Thanks to the Pancreatic Cancer Action Network for sharing Earl's story

and for promoting Precision Promise and the encouraging work of clinical trials for all cancers, but especially for Pancreatic Cancer...

Winging prayers of love and support to Earl and his family,

Keep up the good fight!

In Grace, Tonight,

Always,

Jane